A new drug that is used for Al Zheimer’s disease might actually fixes cavities and regrows teeth.
Thanks to the scientists who developed a drug to treat patients diagnosed with Al Zheimer’s disease “Tideglusib” has the potential to promote natural tooth regrowth mechanism allowing the tooth to repair cavities.
“Tideglusib works by stimulating stem cells in the pulp of teeth, the source of new dentine. Dentine is the mineralized substance beneath tooth enamel that gets eaten away by tooth decay.”
Teeth naturally forms dentine. But for that to happen, the pulp has to be exposed to infection or trauma and that the caries has to be deep enough for the pulp to manufacture dentine. Unfortunately, the rate of caries progression is way higher than the ability of the pulp to generate dentine as a reparative process. Tideglusib works by switching off GSK-3 enzyme which stops dentine from forming.
In the research, the team inserted small, biodegradable sponges made of collagen soaked in Tideglusib into cavities. The sponges triggered dentine growth and within six weeks, the damage was repaired. The collagen structure of the sponges melted away, leaving only the intact tooth.
Who knows that one day this will lead to a new era of dental treatments & caries prevention!